|
KMID : 1123920080220051256
|
|
Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 5 p.1256 ~ p.1261
|
|
|
Effect of Samjahwadam-jeon on CD4, CD8 Cells in OVA-induced Asthmatic Mice
|
|
Nam Tae-Heung
Park Yang-Chun
|
|
|
Abstract
|
|
|
|
This study aimed to examine the effects of Samjahwadam-jeon (SJHDJ) on T cells and T cells in ovalbumin (OVA)-induced asthmatic mice. C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (four a week) for asthma induction. Two experimental groups were treated with different concentrations of SJHDJ (400 mg/kg and 200 mg/kg) extract and cyclosporin A (10 mg/kg) for the later 8 weeks. At the end of the experiment, the mice lung, peripheral lymph node (PLN), and spleen were removed and T cells and T cells for analyzed by flow cytometer. Number of T cells in lung, PLN and spleen of the SJHDJ group (400 mg/kg and 200 mg/kg) were significantly decreased compared with that of control group. Number of T cells in PLN and spleen of the SJHDJ group (400 mg/kg, 200 mg/kg) were significantly decreased compared with that of control group. Conclusion: These results suggest that SJHDJ alleviated asthmatic hyperreactivity through and T cells. Further study of relative cytokines is expected.
|
|
|
KEYWORD
|
|
|
Samjahwadam-jeon (Sanzihuatan-jian), asthma T cells T cells
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|